State-of-the-Art System Promises Continuous, Real-Time Tumor Tracking Without Additional Ionizing Radiation 

Calypso® Medical Technologies, Inc., Investigators Present Progress at AAPM 48th Annual Meeting 

Seattle, WA – July 27, 2006 – Clinical investigation reports on Calypso Medical’s Calypso® 4D Localization System will be presented at the American Association of Physicists in Medicine (AAPM) 48th Annual Meeting July 30 – August 3, at the Orange County Convention Center in Orlando, FL. These reports discuss the Calypso System with permanently implanted Beacon™ Electromagnetic Transponders, which is pending 510(k) clearance. The system is designed to provide efficient, objective, accurate and continuous, real-time tumor localization and tracking capability. For the first time, the clinician is able to measure and monitor the precise position and motion of the tumor during external beam radiation therapy delivery without adding ionizing radiation. 

Calypso® Medical recently completed clinical studies for continuous, real-time localization and tracking prostate tumors undergoing radiation therapy treatment, totaling more than 1,500 treatment sessions. These studies represent the world’s first continuous inter- and intra-fraction prostate motion analysis. Additional investigations for lung, head and neck cancer applications and the use of AC electromagnetic tracking with IGRT technology will be highlighted in abstracts presented at the AAPM 48th Annual Meeting and published simultaneously in the journalMedical Physics:

• Characterization of Cardiac Motion in the Lung Using a Novel Electromagnetic System in an Animal Model
  Presented by K. Lechleiter, B.S., Washington University Medical School, St. Louis, MO; July 31, 1:30 – 3:20 p.m., Valencia B
• Commissioning an AC Electromagnetic Localization System for Radiation Therapy
  Presented by T. Willoughby, M.S., M. D. Anderson Cancer Center Orlando, FL; July 31, 1:30 – 3:20 p.m., Valencia B
• Concurrent Tracking and Fluoroscopic Imaging of Implantable Wireless Electromagnetic Transponders
  Presented by K. Malinowski, Washington University Medical School, St. Louis, MO; July 31, 1:30 – 3:20 p.m., Valencia B
• A Novel Use of Real-Time Tumor Positioning System in Reducing Cone Beam CT Artifacts 060728_1
  Presented by P. Parikh, M.D., Washington University Medical School, St. Louis, MO; July 30, 3:00 – 4:30 p.m., Exhibit Hall F
• Fiducial-Based Translation Alignment Accuracy of an AC Electromagnetic Tracking System and On-Board Kilovoltage Imaging Localization System
  Presented by L. Santanam, Ph.D., Washington University, St. Louis, MO; July 30, 3:00 – 4:30 p.m., Exhibit Hall F
• Assessment of Dental Amalgam Backscatter With a Beacon® Electromagnetic Transponder Embedded Mouthpiece for Real-Time Tracking During Head and Neck IMRT
  Presented by J. Yi, M.S., Swedish Medical Center, Seattle, WA; July 30, 3:00 – 4:30 p.m., Exhibit Hall F

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